A buffer is prepared using acetic acid, CH3COOH, (a weak acid) and sodium acetate, CH3COONa (which provides acetate ions, the conjugate base), according to the following proportions: Volume of CH3COOH(aq): 131.0 mL Concentration . In acid-base chemistry, a salt is defined as the ionic compound that results from a neutralization reaction between an acid and a base. Sodium Acetate Injection, USP should be given to a pregnant woman only if clearly needed. If you are allergic to sodium acetate; any part of sodium acetate; or any other drugs, foods, or substances. Examples include: An example of an acid salt is one containing any of these cations with a neutral base, such as ammonium chloride (NH4Cl). Predict the pH of a solution of a salt containing cations and anions, both of which participate in hydrolysis. Select one or more newsletters to continue. WARNING: This product contains aluminum that may be toxic. It actually makes .04 molar acetate … Excessive administration of potassium free solutions may result in significant hypokalemia. Acetic acid in the buffer solution will react with the addition of … So in solution, we're gonna have sodium ions, Na+, and acetate anions, CH3COO-, and the sodium cations aren't going to react with water, but the acetate anions will. This is useful especially in … FOR ADDITIVE USE ONLY AFTER DILUTION IN INTRAVENOUS FLUIDS. 1 Product Result So an example would be acetic acid, CH3COOH, and that's our weak acid, and we might combine that in solution with sodium acetate. It comprises more than 90% of total cations at its normal plasma concentration of approximately 140 mEq/liter. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. An example of a buffer that consists of a weak base and its salt is a solution of ammonia (\(\ce{NH3(aq)}\)) and ammonium chloride (\(\ce{NH4Cl(aq)}\)). From the previous concept, we know that salts containing the bicarbonate ion (HCO3–) are basic, whereas salts containing bisulfate ion (HSO4–) are acidic. The dose and rate of administration are dependent upon the individual needs of the patient. From solubility rules, you know that sodium acetate dissociates completely in solution, making it a strong electrolyte. In that case, we normally make a mixture of a weak acid plus a weak base, and that weak base might either just be a weak base like ammonia, or it might be a salt with the conjugate base of our weak acid. For hanger application, peel off the paper liner from both ends of the tape hanger to expose ¾ inch long adhesive portions. Basic salts contain the conjugate base of a weak acid, so when they dissolve in water, they react with water to yield a solution with pH greater than 7.0. K_b=([HB^+][OH^-])/([B]) where: [B] is the concentration of the base [HB^+] is the concentration of base … Therefore, a soluble acetate salt, such as sodium acetate will release acetate ions into the solution, which a few of these will interact … sodium acetate - a strong base and a weak acid. A mixture of acetic acid and sodium acetate is acidic because the K a of acetic acid is greater than the K b of its conjugate base acetate. Share Improve this answer The free metal does not occur in … The reactions are as follows: [latex]\text{NH}_4^+(\text{aq})+\text{H}_2\text{O}(\text{l})\rightleftharpoons \text{H}_3\text{O}^+(\text{aq})+\text{NH}_3(\text{aq})\quad\quad \text{K}_\text{a}=5.6\times10^{-10}[/latex], [latex]\text{HCO}_3^-(\text{aq})+\text{H}_2\text{O}(\text{l})\rightleftharpoons \text{H}_2\text{CO}_3(\text{aq})+\text{OH}^-(\text{aq})\quad\quad \text{K}_\text{b}=2.4\times 10^{-8}[/latex]. Sodium acetate dosing is very similar to the dosing used for sodium bicarbonate, however, sodium acetate should be given over 15-20 min (not as a rapid IV bolus). It must not be administered undiluted. Explanation: Acetic acid have an acidic character so it will react with bases to form salts keeping the pH constant. Sodium Acetate Injection, USP (2 mEq/mL) must be diluted before use. Sodium acetate will react with an acid (stronger than the acetic acid) and doing that will keep the pH constant in … Sodium acetate is used as the carbon source for culturing bacteria. Distributed by Hospira, Inc., Lake Forest, IL 60045 USA May contain acetic acid for pH adjustment; the pH is 6.5 (6.0 to 7.0). Hence, sodium acetate is basic in aqueous medium. Novaplus is a registered trademark of Vizient, Inc. Pharmacy Bulk Package. The conjugate acid of the weak base makes the salt acidic. Sodium acetate is a product of a reaction between sodium hydroxide (strong base) and acetic acid (weak acid). In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. K_b=([HB^+][OH^-])/([B]) where: [B] is the concentration of the base [HB^+] is the concentration of base … Medically reviewed by Drugs.com. There are several varieties of salts, and in this section we will consider basic salts. Therefore, it reacts with water in the following fashion: [latex]\text{HCO}_3^-(\text{aq})+\text{H}_2\text{O}(\text{l})\rightleftharpoons \text{H}_2\text{CO}_3(\text{aq})+\text{OH}^-(\text{aq})[/latex]. Plasmafusin Solutions containing sodium ions should be used with great care, if at all, in patients with congestive heart failure, severe renal insufficiency and in clinical states in which there exists edema with sodium retention. sodium chloride. I suppose the sodium tastes like salt and the acetate like acetic acid aka vinegar. This is an acid-base reaction Hydrochloric acid or HCl is a strong acid consisting of one hydrogen atom combined with one chlorine atom. Ans: Sodium acetate (CH3COONa) is a solid-state salt that can not be used in anhydrous or liquid form as an acid or base. For a generalized anion B–, the net ionic reaction is: [latex]\text{B}^-(\text{aq})+\text{H}_2\text{O}(\text{l})\rightleftharpoons \text{BH}(\text{aq})+\text{OH}^-(\text{aq})[/latex]. But because HCl is a strong acid, the Cl– ion is not basic in solution, and it isn’t capable of deprotonating water. Discard any unused portion within 4 hours after initial closure entry. The solution is administered after dilution by the intravenous route as an electrolyte replenisher. Adhere each end to the label on the bottle. Sodium Acetate, 3M, pH 5.2, Molecular Biology Grade - CAS 127-09-3 - Calbiochem. The anion is the conjugate base of a weak acid. It is an inexpensive chemical that has a wide range of uses, including as a food additive and pickling agent or a laboratory reagent. sodium acetate in water for injection. Mixtures of Acids and Bases As has been discussed previously, the acid-base properties of compounds can be utilized to selectively extract certain compounds from mixtures. It is a mixture of weak acid and the base formed by the weak acid when it donates one proton. For example, the acetate ion is the conjugate base of acetic acid, a weak acid. Sodium acetate (CH3COONa) is a salt in solid state and can't be regarded as an acid or base in anhydrous or molten form. These acetic acid derivatives find very diversified applications. The solution contains no bacteriostat, antimicrobial agent or added buffer. The pH of basic salt is more than 7. SODIUM ACETATE TRIHYDRATE. Acetate (CH3COO-) is a hydrogen ion acceptor. 329 matches found for sodium acetate Advanced Search | Structure Search Sort By Relevance Name ↑ Name ↓ Base Name ↑ Base Name ↓ Formula Weight ↑ Formula Weight ↓ Discard unused portion. Sodium acetate is written with the organic component first followed by the cation, as is usual for organic salts. Another example of a buffer is a solution containing ammonia (NH 3, a weak base) and ammonium chloride (NH 4 Cl, a salt derived from that base). Anilinium chloride: Anilinium chloride is an example of an acid salt. It must not be administered undiluted. Sodium acetate, NaC 2 H 3 O 2, is an example.When it dissolves, it forms sodium ions, Na +, and acetate ions, C 2 H 3 O 2 −.The latter react with water in a reversible fashion to form acetic acid molecules, HC 2 H 3 O 2, and hydroxide ions, OH −. This conversion has been shown to proceed readily, even in the presence of severe liver disease. Acid salts contain a hydrolyzable proton in the cation, anion, or both; for instance, the salt ammonium bisulfate (NH, To determine the acidity / alkalinity of a hydrolyzable anion, compare the K. Basic salts result from the neutralization of a strong base with a weak acid. Acetate is metabolized in muscle to acetyl-CoA which is later used in the TCA cycle where bicarbonate is produced. When dissolved in water, acidic salts form solutions with pH less than 7.0. Transfer individual doses to appropriate intravenous infusion solutions. It is also not known whether Sodium Acetate Injection, USP can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. The solution is administered after dilution by the intravenous route as an electrolyte replenisher. The unbalanced chemical equation that describes this neutralization reaction looks like this #"CH"_ 3"COOH"_ ((aq)) + "NaOH"_ ((aq)) -> "CH"_ 3"COONa"_ ((aq)) + "H"_ 2"O"_ ((l))# Now, you could check to see if this chemical equation is balanced by counting the … Remember that when the acid reacts with sodium hydroxide we actually make more base, So we have to adjust the concentration of A minus upward. Sodium acetate salt, or simply sodium acetate, has many practical uses. Since its parent acid is weak, and its … Figure 1. The component ions in a salt can be inorganic; examples include chloride (Cl−), the organic acetate (CH3COO−), and monatomic fluoride (F−), as well as polyatomic ions such as sulfate (SO42−). CC licensed content, Specific attribution, http://en.wikipedia.org/wiki/Salt_(chemistry), http://www.boundless.com//chemistry/definition/basic-salt, http://www.boundless.com//chemistry/definition/acid-salt, http://commons.wikimedia.org/wiki/File:AniliniumChloride.png, http://www.boundless.com//chemistry/definition/base, http://www.boundless.com//chemistry/definition/neutralization-reaction, http://en.wikipedia.org/wiki/neutralization. We would like to show you a description here but the site won’t allow us. A Pharmacy Bulk Package is a container of a sterile preparation for parenteral use that contains many single doses. As such, salts are composed of cations (positively charged ions ) and anions (negative ions), and in their unsolvated, solid forms, they are electrically neutral (without a net charge). Dosage Form: injection, solution, concentrate. Notice that for all of these examples, the anion is the conjugate base of a weak acid (carbonic acid, bisulfate (second dissociation step of sulfuric acid), acetic acid, hydrocyanic acid, hydrogen sulfide). Acetate Buffer Calculator. A mixture of a weak acid and its conjugate base (or a mixture of a weak base and its conjugate acid) is called a buffer solution, or a buffer.Buffer solutions resist a change in pH when small amounts of a strong acid or a strong base are added ().A solution of acetic acid and sodium acetate (CH 3 COOH + CH 3 COONa) is an example of a buffer that consists of a weak acid and its salt. ammonium nitrate- strong acid, weak base. Acetic acid, sodium salt, trihydrate. potassium nitrate - strong acid, strong base. When dissolved in water, a basic salt yields a solution with pH greater than 7.0. Example: A buffer solution was made by dissolving 10.0 grams of sodium acetate in 200.0 mL of 1.00 M acetic acid. The solution is administered after dilution by the intravenous route as an electrolyte replenisher. Each mL contains 164 mg of Sodium Acetate (anhydrous) which provides 2 mEq each of sodium (Na+) and acetate (CH3COO-). Most reactions of a weak acid with a weak base also go essentially to completion. It must not be administered undiluted. An acetic acid buffer solution is required to … The appearance is a white odorless powder, and it comes from a reaction between acetic acid with sodium carbonate. The contents are intended for use in a pharmacy admixture program and are restricted to the preparation of admixtures for intravenous infusion. Sodium acetate can be used to give a vinegar flavor to potato chips. An example of a buffer that consists of a weak base and its salt is a solution of ammonia and ammonium chloride (NH 3 (aq) + NH 4 Cl (aq)). A solution which has a stable pH is termed as a buffer solution. It contains an acetate. However, as we have already discussed, the ammonium ion acts as a weak acid in solution, while the bicarbonate ion acts as a weak base. Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Now, as NaOH is a strong base and CH3COOH is a weak acid, the resultant solution is basic in nature. Tell your doctor about the allergy and what signs you had. An acidic buffer is a solution of a weak acid (acetic acid) and its conjugate base pair (sodium acetate) that prevents the pH of a solution from changing drastically through the action of each component with incoming acid or base. Therefore, bicarbonate is a slightly more alkaline than ammonium is acidic, and a solution of ammonium bicarbonate in pure water will be slightly basic (pH > 7.0). Acid salts are the converse of basic salts; they are formed in the neutralization reaction between a strong acid and a weak base. The solution is intended as an alternative to sodium chloride to provide sodium ion (Na+) for addition to large volume infusion fluids for intravenous use. We determined that 80.1 ± 2.3% of an exogenous source of acetate is oxidized in humans at rest. Sodium Acetate, USP anhydrous is chemically designated CH3COONa, a hygroscopic powder very soluble in water. Such increased acetate availability has resulted in acetate oxidation contributing up … This is useful especially in … alkaline, earthy, metallic, nonmetallic or radical base). Tissue loading may occur at even lower rates of administration. The above process should be carried out under a laminar flow hood using aseptic technique. The osmolar concentration is 4 mOsmol/mL (calc. There are, however, many situations where acetate availability is increased, such as following ethanol ingestion (4,5), following an increased consumption of dietary fiber (6,7) and during renal dialysis using acetate (8,9). When dissolved in water, acidic salts will yield solutions with pH less than 7.0. Sodium Acetate Injection, USP (2 mEq/mL) is contraindicated in patients with hypernatremia or fluid retention. We can determine the answer by comparing Ka and Kb values for each ion. The K a for acetic acid is 1.7 x 10-5. The solution contains no bacteriostat, antimicrobial agent or added buffer. Acetate should be administered with great care in those conditions in which there is an increased level or an impaired utilization of this ion, such as severe hepatic insufficiency. Acetic acid neutralizes added base, and sodium acetate neutralizes added acid. The intravenous administration of this solution (after appropriate dilution) can cause fluid and/or solute overloading resulting in dilution of other serum electrolyte concentrations, overhydration, congested states or pulmonary edema. The ammonium ion contains a hydrolyzable proton, which makes it an acid salt. One example is the reaction of acetic acid with ammonia: Admixtures must be stored under refrigeration and used within 24 hours after compounding. Key Difference – Acetic Acid vs Acetate The key difference between acetic acid and acetate is that acetic acid is a neutral compound whereas acetate is an anion having a net negative electrical charge.. Acetic acid is an organic compound that helps to manufacture vinegar while acetate ion is the conjugate base of the acetic acid. Sodium Acetate Injection, USP (2 mEq/mL) is a sterile, nonpyrogenic, concentrated solution of Sodium Acetate in water for injection. Explain the formation of acid salts and their effects on a solution’s pH. Serum sodium should be monitored as a guide to dosage. A buffer solution formed by the mixture of acetic acid and sodium acetate (base formed by acetic acid) is acetate buffer. Each mL contains 164 mg of sodium acetate (anhydrous) which provides 2 mEq each of sodium (Na +) and acetate (CH3COO-). The pH is roughly 8.96. A single entry through the vial closure should be made with a sterile dispensing set or transfer device. In Reply.—Kasik and colleagues criticize our use of sodium acetate in the fluid therapy of premature infants.In our study we set up a goal to avoid variations in osmolality by providing a stable water, sodium, and acid-base balance. Acid salts can also contain an acidic proton in the anion. We determine whether the hydrolyzable ion is acidic or basic by comparing the Ka and Kb values for the ion; if Ka > Kb, the ion will be acidic, whereas if Kb > Ka, the ion will be basic. The reaction proceeds in two steps. Because the strong base NaOH has been converted to the weak base sodium acetate, the pH of the solution won't rise nearly as much as if the acetic acid weren't present in the first place. Sodium acetate is actually used to flavour crisps (potato chips). In the event of overdosage, discontinue infusion containing Sodium Acetate immediately and institute corrective therapy as indicated to reduce elevated serum sodium levels, and restore acid-base balance if necessary (See WARNINGS, PRECAUTIONS and ADVERSE REACTIONS). Geriatric Use: An evaluation of current literature revealed no clinical experience identifying differences in response between elderly and younger patients. "Acetate" also describes the conjugate base or ion (specifically, the negatively charged ion called an anion) typically found in aqueous solution and … Sodium ions are known to be substantially excreted by the kidney, and the risk of toxic reactions may be greater in patients with impaired renal function. The ones that are a bag of liquid with a … Sodium acetate (CH3COONa) is a salt in solid state and can't be regarded as an acid or base in anhydrous or molten form. It is the conjugate base of a weak acid, meaning that it only partially ionizes when dissolved in water. In this case, the value of Kb for bicarbonate is greater than the value of Ka for ammonium. Pregnancy: Animal reproduction studies have not been conducted with Sodium Acetate Injection, USP. Supposing you’re trying to make sodium acetate from acetic acid and sodium bicarbonate in a lab setting, a good hypothesis would be that if sodium bicarbonate and acetic acid were to be allowed to react together, then they would produce dihydrogen monoxide, carbon dioxide, and sodium acetate. Sodium acetate is the sodium salt of acetic acid. Sodium overload can occur with intravenous infusion of excessive amounts of sodium-containing solutions (See WARNINGS and PRECAUTIONS). Use of a syringe with needle is not recommended as it may cause leakage and multiple entries will increase the potential of microbial and particulate contamination. Sodium acetate is also useful for increasing yields of DNA isolation by ethanol precipitation. A solution of acetic acid (\(\ce{CH3COOH}\) and sodium acetate \(\ce{CH3COONa}\)) is an example of a buffer that consists of a weak acid and its salt. The sodium ion exerts a primary role in controlling total body water and its distribution. Now, with NaOH being a strong base and CH3COOH being a weak acid, the resulting solution is fundamental in nature. Acetate is quickly converted to acetyl-CoA by the enzyme acetyl-CoA synthetase, with the oxidation of acetate reported to account for between 5 and 13% of total energy expenditure at rest and in the fasted state (1–3). Since sodium acetate is the salt formed from sodium hydroxide (a strong base) and acetic acid (a weak acid) a solution of the salt should be alkaline. 6131-90-4. The Pharmacy Bulk Package is for use in the Pharmacy Admixtures Service only. It is also useful as an additive for preparing specific intravenous fluid formulas when the needs of the patient cannot be met by standard electrolyte or nutrient solutions. Now, as NaOH is a strong base and CH3COOH is a weak acid, the resultant solution is basic in nature. Ans: Sodium acetate (CH3COONa) is a solid-state salt that can not be used in anhydrous or liquid form as an acid or base. Sodium Acetate Injection, USP (2 mEq/mL) is a sterile, nonpyrogenic, concentrated solution of Sodium Acetate in water for injection. Sodium acetate is the salt of a weak acid and strong base from the equation: C_(2)H_(3)NaO_2->CH_3COO^(-)+Na^(+), where: CH_3COO^(-)+H_2O\\rightleftharpoonsCH_3COOH+OH^(-) As it is a weak acid and strong base, this is a good indicator of a fairly high pH. As we have discussed, salts can form acidic or basic solutions if their cations and/or anions are hydrolyzable (able to react in water). An acetate / ˈæsɪteɪt / is a salt formed by the combination of acetic acid with a base (e.g. So the acetate anion is the conjugate base to acetic acid. Sodium acetate (NaOOCCH 3) Potassium cyanide (KCN) Sodium sulfide (Na 2 S) Notice that for all of these examples, the anion is the conjugate base of a weak acid (carbonic acid, bisulfate (second dissociation step of sulfuric acid), acetic acid, hydrocyanic acid, hydrogen sulfide). Sodium Acetate Injection, USP (2 mEq/mL) is supplied in Pharmacy Bulk Packages as follows: Store at 20 to 25ºC (68 to 77ºF). Distinguish basic salts from non-basic salts. Certain ionic compounds with anions other than hydroxide are weak Arrhenius bases. Sodium chloride, for instance, contains chloride (Cl–), which is the conjugate base of HCl. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Salts with acidic protons in the cation are most commonly ammonium salts, or organic compounds that contain a protonated amine group. Keep in mind that a salt will only be basic if it contains the conjugate base of a weak acid. Thomaegelin. It also serves as an alternate source of bicarbonate (HCO3-) by metabolic conversion in the liver. A good example of such a salt is ammonium bicarbonate, NH4HCO3; like all ammonium salts, it is highly soluble, and its dissociation reaction in water is as follows: [latex]\text{NH}_4\text{CO}_3(\text{s})\rightarrow \text{NH}_4^+(\text{aq})+\text{HCO}_3^-(\text{aq})[/latex]. Once it’s dissolved, the acetate ion, which is the conjugate base of acetic acid, will act as a base and accept protons, slightly raising the pH. The vials should be suspended as a unit in the laminar flow hood. If you have high sodium levels or swelling. Defined as the carbon source for culturing bacteria explain the formation of acid salts and effects... Molecular Biology Grade - CAS 127-09-3 - Calbiochem of trauma patients is presented HCl is a hydrogen ion.! Contains the conjugate base of a weak acid the chemical formula C2H3O2Na and also... Comparing Ka and Kb values for each ion with anions other than hydroxide are weak bases... 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By dissolving 10.0 grams of sodium acetate - a strong acid and a weak acid with a base! Diluted before use the value of Kb for bicarbonate is produced by hydroxide. As an alternate source of bicarbonate ( HCO3- ) by metabolic conversion in the presence of severe disease. To adolescent t allow us comparing Ka and Kb values for each ion acid! Ammonium bicarbonate be acidic or basic and in buffer solutions to adolescent unless solution basic!, contain cations and anions that can both undergo hydrolysis protonated amine group buffer. Isolation by ethanol precipitation trademark of Vizient, Inc. Pharmacy Bulk Package is a registered trademark Vizient!, as NaOH is a basic solution, sodium acetate, USP ( 2 mEq/mL ) is contraindicated patients... They do react with a strong base ) adjustmen… sodium acetate in water under a laminar flow hood using technique. Use in a Pharmacy admixture program and are restricted to the label on bottle! 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Has a stable pH is termed as a unit in the salt is sodium bicarbonate reacts with reaction... Usa Novaplus is a mixture of acetic acid have an acidic proton the... By acetic acid neutralizes added base, sodium acetate ( base formed by acid. ( NH4HCO3 ), contain cations and is sodium acetate a base, both of which participate hydrolysis. The TCA cycle where bicarbonate is produced by sodium hydroxide ( strong base and is..., concrete manufacture, heating pads and in buffer solutions easiest way to lookup drug information, identify,... Program and are restricted to the is sodium acetate a base on the bottle ( weak acid sodium... Is defined as the carbon source for culturing bacteria excess administration may result in significant.. Clearly needed the carbon source for culturing bacteria shown to proceed readily, even the. Parenteral FLUIDS, especially those containing sodium ions, to patients receiving corticosteroids or corticotropin expose ¾ inch adhesive. The intravenous route as an electrolyte replenisher aluminum may reach toxic levels with prolonged parenteral if... Visually for particulate matter and discoloration prior to administration ( See WARNINGS PRECAUTIONS... It comes from a neutralization reaction is the conjugate base of a sterile dispensing set or transfer device many doses! They do react with a sterile preparation for parenteral use that contains many single.... To form sodium acetate and carbonic acid is a sterile dispensing set or transfer device excess... Yielding a basic salt is the reaction is also an example of an acid a. Naoh is a base determine the answer by comparing Ka and Kb values for ion! The weak acid, solution, sodium acetate Injection, USP ( 2 )! Acid-Base chemistry, a weak base also go essentially to completion ions may result in significant.! On more than 24,000 prescription drugs, foods, or organic compounds that from! Its distribution the formation of acid salts result from the neutralization reaction an! Hydrogen ion acceptor acid-base neutralization reaction between acetic acid aka vinegar thereby raising the solution contains bacteriostat. To administration ( See WARNINGS and PRECAUTIONS ) to a pregnant woman only if needed! Ionic compounds that result from the neutralization reaction between acetic acid is an example of an acid-base reaction., alerts and updates heating pads and in this section we will consider basic.. Current literature revealed no clinical experience identifying differences in response between elderly and younger patients acid added... Reaction of acetic acid an evaluation of current literature revealed no clinical experience identifying differences in between. A solution ’ s pH acetate and carbonic acid, a weak acid and sodium acetate in 200.0 of! Many single doses with acidic protons in the anion in the anion 4 Raman electrolyte replenisher ethanol precipitation is.
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